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You should not use ticagrelor if you are allergic to it, or if you have:

• severe liver disease;

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Do not use Brilinta within 5 days before heart bypass surgery (coronary artery bypass graft, or CABG).

To make sure ticagrelor is safe for you, tell your doctor if you have:

• liver disease;

• a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker);

• asthma, COPD (chronic obstructive pulmonary disorder) or other breathing problem;

• a history of stomach ulcer or colon polyps;

• a history of stroke; or

• a history of bleeding or blood clotting disorder.

Ticagrelor may cause you to bleed more easily, especially if you have:

• a recent surgery or bleeding injury;

• a disease affecting the blood vessels in your brain;

• a history of stroke;

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• a history of stomach or intestinal bleeding; or

• if you are 65 or older.

It is not known whether Brilinta will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

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